Olanzapine was more effective than lorazepam at 2 hours but not at 24 hours in bipolar mania with acute agitation.
نویسنده
چکیده
Patients 201 patients >18 years of age (mean age 40 y, 53% men) who had bipolar disorder, mania, or a mixed diagnosis confirmed with the Structured Clinical Interview for DSMIII-R considered by the site physician to have severe agitation requiring injections and who had a total score >14 on the 5 item Positive and Negative Syndrome Scale-Excited Component (PANSS-EC) scale with >1 individual score of >4. Two patients were not included in the analysis.
منابع مشابه
Olanzapine versus divalproex sodium for the treatment of acute mania and maintenance of remission: a 47-week study.
OBJECTIVE Few double-blind trials have compared longer-term efficacy and safety of medications for bipolar disorder. The authors report a 47-week comparison of olanzapine and divalproex. METHOD This 47-week, randomized, double-blind study compared flexibly dosed olanzapine (5-20 mg/day) to divalproex (500-2500 mg/day) for manic or mixed episodes of bipolar disorder (N=251). The only other psy...
متن کاملIntramuscular olanzapine in the management of acute agitation.
OBJECTIVE To review the current efficacy and safety evidence for the use of intramuscular olanzapine in the management of acute agitation. DATA SOURCES MEDLINE, EMBASE, and PubMed (all to March 2004) were searched for full-text, English-language publications in humans. Search terms included olanzapine, psychosis, agitation, psychiatric emergency, and intramuscular. STUDY SELECTION AND DATA ...
متن کاملOlanzapine reduces mania more effectively than divalproex, but has more adverse effects.
Participants 248 adults hospitalised with acute bipolar manic or mixed episodes, with or without psychotic features (confirmed with Structured Clinical Interview for DSM-IV and minimum score of 20 on the Young Mania Rating Scale at both screening and randomisation); mean age 41 years (range 18–75); 57% women. Exclusion criteria were unstable or serious medical illness; DSM-IV drug or alcohol de...
متن کاملRapid tranquilization of severely agitated patients with schizophrenia spectrum disorders: a naturalistic, rater-blinded, randomized, controlled study with oral haloperidol, risperidone, and olanzapine.
INTRODUCTION Agitation is a major problem in acute schizophrenia. Only a few studies have tested antipsychotic agents in severely agitated patients, mainly because of legal issues. Furthermore, most studies were limited to the first 24 hours. We aimed to investigate the efficacy of oral haloperidol, risperidone, and olanzapine in reducing psychotic agitation in severely agitated patients with s...
متن کاملA double-blind, placebo-controlled dose-response comparison of intramuscular olanzapine and haloperidol in the treatment of acute agitation in schizophrenia.
BACKGROUND An intramuscular (IM) formulation of olanzapine has been developed because there are no rapid-acting IM atypical antipsychotic drugs currently available in the United States for treating acute agitation in patients with schizophrenia. METHODS Recently hospitalized acutely agitated patients with schizophrenia (N = 270) were randomized to receive 1 to 3 IM injections of olanzapine (2...
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ورودعنوان ژورنال:
- Evidence-based mental health
دوره 5 1 شماره
صفحات -
تاریخ انتشار 2002